The electro-mechanical braking system of distributed driving multi-axis vehicles can apply the regenerative braking energy of its wheel motors to improve the vehicle’s braking performance. The deformation coordination model of suspension of the multi-axle vehicle is used to calculate the axial load transfer with different braking strengths， and the braking force distribution coefficient among the axles of the multi-axle vehicle is designed based on ECE regulations. A co-simulation model of electro-mechanical hybrid braking system is established which includes hysteresis characteristics of the air brake system. The rule-based braking control strategy is formulated to discuss the possible topological configuration of the electro-mechanical hybrid braking system. The braking performance of removing air brake component on some axes and the reduction of gas capacity is studied under the premise of ensuring the vehicle’s safety. Thus， the braking system of the vehicle can be simplified， and the available space of the vehicle chassis can be enlarged.