A mechanical model of Shenzhen Bay Bridge was established, which considered the hanging degree of cable, and the finite element software was used to simulate the displacement response of the bridge deck and tower anchor points when the seismic, wind, vehicles and other loads were acted on the bridge structure, and the dynamic characteristics of the bridge as well as the vibration solution of the connection nodal. The initial disturbance of cable under foundation excitation was revealed, and the harmonic resonance and parametric vibration of cable in the most unfavorable load case were studied. On this basis, the matching ratio of incentive frequency to cable natural frequency was analyzed, and the influencing characteristics of the nonlinear vibration for cable was obtained, which included excitation amplitude, initial force, modal damping ratio and the cable angle.