This paper mainly introduces the position and function of neurodynamic theory in the field of brain science, its present situation and the original innovation of our country, the existing problems and its historical mission. It emphasizes the intrinsic connection, importance and influence of mechanics in neuroscience and life sciences, especially points out that the original innovation in the field of brain science cannot be separated from the role, guidance and contribution of mechanics. The paper also focuses on the main research findings in the special issue. The authors of these findings have separately elaborated from different perspectives on how they apply neurodynamic theory to reveal some unique new phenomena and rule that cannot be discovered in experiments, and the unique power shown in exploring degenerative neurological diseases and cognitive impairment.