Vehicle handling stability response from multiple state variables was considered. A multi-variable stabilization control algorithm for four-wheel steering vehicle based on yaw-rate tracking was put forward. To improve the vehicle dynamic response in a high speed range, the closed-loop simulation model of 4WS system was established. The transient and steady maneuverability of the 4WS vehicle was tested by using the visual prototyping model with the different control algorithms. The results show that the nonzero input of the rear steering angle is suitably controlled according to the 4WS multi-variable stabilization control algorithm，the transient responses of 4WS vehicle will be significantly improved, such as the lateral acceleration and its yaw angular velocity, meanwhile, its steady maneuverability is unchangeable.