As a crucial link of the drivervehicleroad closedloop system, the driver model plays an important role in the simulation of vehicle closeloop system and the evaluation of vehicle active safety. Based on the Vehicle Handling Dynamics, the PreviewFollow theory and the Artificial Neural Network, this paper established a directional control driver model—TwoLayerFeedforward Artificial Neural Network Driver Model and the drivervehicle closed-loop system model. Using the closeloop system model, single and double lane change simulations were performed. The results show good agreement with the ideal data. It indicates that this driver model is reasonable enough to simulate the driver’s behavior property and provide a feasible way to the further investigation of the drivervehicleroad closedloop system.